Diretrizes clínicas da ABRAMEDE para o manejo de dengue em pacientes adultos na emergência

Autores

  • Lucas Oliveira J. e Silva Universidade Federal do Rio Grande do Sul https://orcid.org/0000-0001-5388-9163
  • Rafael von Hellmann Monash Health
  • Ian Ward A. Maia Hospital das Clínicas da Universidade de São Paulo
  • Rodrigo Brandão Hospital das Clínicas da Universidade de São Paulo
  • Daniel Schubert Universidade do Estado do Rio de Janeiro
  • Júlio Marchini Hospital das Clínicas da Universidade de São Paulo
  • Uri Adrian Prync Flato Faculdade Israelita de Ciências em Saúde Albert Einstein
  • Patrícia Lopes Hospital Geral de Fortaleza
  • Ariane Coester Hospital de Clínicas de Porto Alegre
  • Maria Camila Lunardi Hospital São Paulo
  • Hamilton Rocha Universidade Estadual de Campinas
  • Vinicius Ortigosa Nogueira Universidade Federal de Rondônia
  • Kaile de Araújo Cunha Hospital UDI Rede D’Or
  • Vitor Benincá Universidade do Extremo Sul Catarinense
  • Ludhmila Abrahão Hajjar
  • Júlio César Garcia Alencar Universidade de São Paulo
  • Hélio Penna Guimarães Hospital das Clínicas da Universidade de São Paulo

DOI:

https://doi.org/10.54143/jbmede.v4i2.199

Palavras-chave:

Dengue, Epidemias, Guias como assunto, Emergências, Serviços médicos de emergência

Resumo

No Brasil, a dengue é a arbovirose mais significativa e um dos principais motivos de consultas em Departamentos de Emergência. Em 2024, o país vem enfrentando um número recorde de casos, exacerbando a superlotação das emergências. Diante da grave epidemia, é crucial aprimorar o manejo clínico, para evitar a evolução para formas graves da doença e reduzir a mortalidade. Esta diretriz clínica é dedicada ao manejo de pacientes adultos com suspeita ou quadro confirmado de dengue na emergência, seja em Departamentos de Emergência hospitalares ou unidades de pronto atendimento. A elaboração desta diretriz ocorreu entre fevereiro, março e abril de 2024, por um painel de 17 especialistas. Adotou-se a metodologia GRADE, que segue um processo envolvendo: o desenvolvimento de revisões sistemáticas para as questões priorizadas; a avaliação da certeza das evidências; a formulação de recomendações utilizando o framework GRADE evidence-to-decision. A metodologia GRADE-ADOLOPMENT também foi utilizada para adotar e/ou adaptar revisões sistemáticas e recomendações de outras diretrizes aplicáveis. Dez perguntas clínicas foram priorizadas e respondidas, sendo geradas recomendações com força e nível de evidência variados. Esta é a primeira diretriz da Associação Brasileira de Medicina de Emergência que emprega a metodologia GRADE para fornecer respostas claras e baseadas em evidências às perguntas consideradas mais críticas por especialistas no manejo de pacientes adultos com dengue nas emergências.

Biografia do Autor

Lucas Oliveira J. e Silva, Universidade Federal do Rio Grande do Sul

Professor Adjunto de Medicina de Emergência

Faculdade de Medicina, Universidade Federal do Rio Grande do Sul (UFRGS)

Referências

Kularatne SA. Dengue fever. BMJ. 2015;351:h4661.

Simmons CP, Farrar JJ, Nguyen van VC, Wills B. Dengue. N Engl J

Med. 2012;366(15):1423-32.

Guzman MG, Harris E. Dengue. Lancet Lond Engl.

;385(9966):453-65.

Dengue: Diagnóstico e Manejo Clínico Adulto e Pediátrico.

Accessed October 3, 2024. http://bvsms.saude.gov.br/bvs/

publicacoes/dengue_ diagnostico_manejo_clinico_6ed.pdf

Brasil. Ministério da Saúde. Atualização de casos de arboviroses.

Brasília, DF: Ministério da Saúde; 2024 [citado 2024 Mai 15].

Disponível em: https://www.gov.br/saude/pt-br/assuntos/saudede-

a-a-z/a/aedes-aegypti/monitoramento-das-arboviroses

Centers for Disease Control and Prevention (CDC). Dengue Virus

and Dengue. Module 2. Causes of death. [cited 2024 May 15].

Available from: https://www.cdc.gov/dengue/training/cme/ccm/

page50639.html

7. Zhang Y, Akl EA, Schünemann HJ. Using systematic reviews

in guideline development: the GRADE approach. Res Synth

Methods. 2018.

Alonso-Coello P, Oxman AD, Moberg J, Brignardello-Petersen R,

Akl EA, Davoli M, et al.; GRADE Working Group. GRADE Evidence

to Decision (EtD) frameworks: a systematic and transparent

approach to making well informed healthcare choices. 2: Clinical

practice guidelines. BMJ. 2016;353:i2089.

World Health Organization (WHO). Dengue guidelines for

diagnosis, treatment, prevention and control : new edition.

Geneve: WHO; 2009. [cited 2024 May 15]. Available from:

https://iris.who.int/handle/10665/44188

Organización Panamericana de la Salud. Síntesis de evidencia:

Directrices para el diagnóstico y el tratamiento del dengue, el

chikunguña y el zika en la Región de las Américas. Rev Panam Salud

Publica. 2022;46:e82.

11. Atkins D, Best D, Briss PA, Eccles M, Falck-Ytter Y, Flottorp S,

et al.; GRADE Working Group. Grading quality of evidence and

strength of recommendations. BMJ. 2004;328(7454):1490.

12. Schünemann HJ, Wiercioch W, Brozek J, Etxeandia-Ikobaltzeta

I, Mustafa RA, Manja V, et al. GRADE Evidence to Decision (EtD)

frameworks for adoption, adaptation, and de novo development of

trustworthy recommendations: GRADE-ADOLOPMENT. J Clin

Epidemiol. 2017;81:101-10.

Carpenter CR, E Silva LO, Upadhye S, Broder JS, Bellolio F. A

candle in the dark: The role of indirect evidence in emergency

medicine clinical practice guidelines. Acad Emerg Med Off J Soc

Acad Emerg Med. 2022;29(5):674-7.

Setiawan MW, Samsi TK, Pool TN, Sugianto D, Wulur H. Gallbladder

wall thickening in dengue hemorrhagic fever: An ultrasonographic

study. J Clin Ultrasound. 1995;23(6):357-62.

Setiawan MW, Samsi TK, Wulur H, Sugianto D, Pool TN. Dengue

haemorrhagic fever: ultrasound as an aid to predict the severity of

the disease. Pediatr Radiol. 1998;28(1):1-4.

Gleeson T, Pagnarith Y, Habsreng E, Lindsay R, Hill M, Sanseverino

A, et al. Dengue Management in Triage using Ultrasound in

children from Cambodia: a prospective cohort study. Lancet Reg

Health West Pac. 2022;19:100371.

Chacko B, Subramanian G. Clinical, laboratory and radiological

parameters in children with dengue fever and predictive factors

for dengue shock syndrome. J Trop Pediatr. 2007;54(2):137-40.

Pothapregada S, Kullu P, Kamalakannan B, Thulasingam M. Is

Ultrasound a Useful Tool to Predict Severe Dengue Infection?

Indian J Pediatr. 2016;83(6):500-4.

Bharath Kumar Reddy KR, Laksmana RR, Veerappa BG,

Shivananda. Ultrasonography as a tool in predicting the severity

of dengue fever in children--a useful aid in a developing country.

Pediatr Radiol. 2013;43(8):971-7.

Colbert JA, Gordon A, Roxelin R, Silva S, Silva J, Rocha C, et al.

Ultrasound measurement of gallbladder wall thickening as a

diagnostic test and prognostic indicator for severe dengue in

pediatric patients. Pediatr Infect Dis J. 2007;26(9):850-2.

Raman R, Lakshmi M. Correlation of inferior vena cava ultrasound

with packed cell volume and clinical condition in children with

dengue fever. J Emerg Med Trauma Acute Care. 2016;2016(3).

Srikiatkhachorn A, Krautrachue A, Ratanaprakarn W,

Wongtapradit L, Nithipanya N, Kalayanarooj S, et al. Natural

history of plasma leakage in dengue hemorrhagic fever: a serial

ultrasonographic study. Pediatr Infect Dis J. 2007;26(4):283-90;

discussion 291-2.

Yousaf KR, Atiq S, Sheikh QS, Nisar MS, Khalid S. Sonographic

features of polyserositis as an adjunct to clinico-pathological

parameters in diagnosing and predicting the severity of dengue

fever. Pakistan Journal of Medical & Health Sciences 5(1):184-9.

Khurram M, Qayyum W, Umar M, Jawad M, Mumtaz S, Khaar HT.

Ultrasonographic pattern of plasma leak in dengue haemorrhagic

fever. J Pak Med Assoc. 2016;66(3).

Adil B, Rabbani A, Ahmed S, Arshad IS, Khalid MA. Gall bladder wall

thickening in dengue fever - aid in labelling dengue hemorrhagic

fever and a marker of severity. Cureus. 2020;12(11):e11331.

Tavares MD, João GA, Bastos MS, Gimaque JB, Almeida AD,

Ngo TT, et al. Clinical relevance of gallbladder wall thickening for

dengue severity: A cross-sectional study. Schildgen O, ed. PLOS

ONE. 2019;14(8):e0218939.

Ibrahim MA, Hamzah SS, Md Noor J, Mohamad MIK, Mokhtar

MF, Isa MR, et al. The association of ultrasound assessment of

gallbladder wall thickness with dengue fever severity. Ultrasound

J. 2022;14(1):13

Xin Tian C, Baharuddin KA, Shaik Farid AW, Andey R, Ridzuan MI,

Siti-Azrin AH. Ultrasound findings of plasma leakage as imaging

adjunct in clinical management of dengue fever without warning

signs. Med J Malaysia. 2020;75(6):635-41

Michels M, Sumardi U, de Mast Q, Jusuf H, Puspita M, Dewi

IM, et al. The predictive diagnostic value of serial daily bedside

ultrasonography for severe dengue in Indonesian adults. PLoS

Negl Trop Dis. 2013;7(6):e2277.

Sigera PC, Weeratunga P, Deepika Fernando S, Lakshitha De Silva

N, Rodrigo C, Rajapakse S. Rational use of ultrasonography with

triaging of patients to detect dengue plasma leakage in resource

limited settings: a prospective cohort study. Trop Med Int Health.

;26(8):993-1001.

Quiroz-Moreno R, Méndez GF, Ovando-Rivera KM. Utilidad

clínica del ultrasonido en la identificación de dengue hemorrágico.

Rev Med Inst Mex Seguro Soc. 2006;3.

Lakshman A, Balasubramanian P, Nampoothiri RV, Vijayvergiya

R, Bhalla A, Varma SC. Elevated cardiac biomarkers and

echocardiographic left ventricular dysfunction at admission in

patients with dengue fever: report from a tertiary care center in

Northwest India. Trop Doct. 2018;48(4):261-5.

Thulkar S, Sharma S, Srivastava DN, Sharma SK, Berry M, Pandey

RM. Sonographic findings in grade III dengue hemorrhagic fever in

adults. J Clin Ultrasound JCU. 2000;28(1):34-7.

Sharma N, Mahi S, Bhalla A, Singh V, Varma S, Ratho RK. Dengue

fever related acalculous cholecystitis in a North Indian tertiary

care hospital. J Gastroenterol Hepatol. 2006;21(4):664-7.

Wu KL, Changchien CS, Kuo CH, Chiu KW, Lu SN, Kuo CM, et

al. Early abdominal sonographic findings in patients with dengue

fever. J Clin Ultrasound. 2004;32(8):386-8.

Ultrasound guidelines: emergency, point-of-care and

clinical ultrasound guidelines in medicine. Ann Emerg Med.

;69(5):e27-e54.

Sorensen B, Hunskaar S. Point-of-care ultrasound in primary

care: a systematic review of generalist performed point-ofcare

ultrasound in unselected populations. Ultrasound J.

;11(1):31.

Dupriez F, Geukens P, Penaloza A, Vanpee D, Bekkering G, Bobbia

X. Agreement of emergency physician-performed ultrasound

versus RADiology-performed UltraSound for cholelithiasis or

cholecystitis: a systematic review. Eur J Emerg Med. 2021;28(5).

Elgassim M, Almarri ND, Basharat K, Azad AM. Advancement in

pleura effusion diagnosis: a systematic review and meta-analysis

of point-of-care ultrasound versus radiographic thoracic imaging.

Ultrasound J. 2024;16(1):3.

Huffman JL, Schenker S. Acute acalculous cholecystitis: a review.

Clin Gastroenterol Hepatol Off Clin Pract J Am Gastroenterol

Assoc. 2010;8(1):15-22.

Whiting PF. QUADAS-2: A Revised Tool for the Quality

Assessment of Diagnostic Accuracy Studies. Ann Intern Med.

;155(8):529.

Pellegrini JA, Cordioli RL, Grumann AC, Ziegelmann PK, Taniguchi

LU. Point-of-care ultrasonography in Brazilian intensive care units:

a national survey. Ann Intensive Care. 2018;8(1):50.

Gracias VH, Frankel HL, Gupta R, Malcynski J, Gandhi R, Collazzo

L, et al. Defining the learning curve for the Focused Abdominal

Sonogram for Trauma (FAST) examination: implications for

credentialing. Am Surg. 2001;67(4):364-8.

Tambelli RA, Silva PS, Schubert DU, Nogueira VO, Gaspar PL,

Oliveira KF, et al. Extended Focused Assessment Sonography

in Dengue (E-Fasd): protocolo de ultrassom point of care para

avaliação de pacientes com dengue. JBMEDE. 2024;4(1): e24005.

Hernández G, Ospina-Tascón GA, Damiani LP, Estenssoro E, Dubin

A, Hurtado J, et al.;. Effect of a Resuscitation Strategy Targeting

Peripheral Perfusion Status vs Serum Lactate Levels on 28-Day

Mortality Among Patients With Septic Shock: The ANDROMEDASHOCK

Randomized Clinical Trial. JAMA. 2019;321(7):654-64.

46. World Health Organization (WHO). Dengue Haemorrhagic

Fever: Diagnosis, Treatment, Prevention, and Control. 2nd ed.

WHO; 1997.

47. Khwaja A. KDIGO clinical practice guidelines for acute

kidney injury. Nephron Clin Pract. 2012;120(4):c179-184.

Lauque D, Khalemsky A, Boudi Z, Östlundh L, Xu C, Alsabri M, et

al. Length-of-Stay in the Emergency Department and In-Hospital

Mortality: A Systematic Review and Meta-Analysis. J Clin Med.

;12(1):32.

Conselho Federal de Medicina (CFM). Resolução CFM

no 2.077/14. Brasília, DF: CFM; 2014 [citado 2024 Mai

. Disponível em: https://portal.cfm.org.br/images/PDF/

resolucao2077.pdf

Borghi D, Canetti MD, Braz W, Cortes L, Vasconcellos RC. Field

hospital for fluid intake: The solution for the decrease mortality in

dengue fever. Int J Infect Dis. 2010;14:e45.

Marra AR, Matos GF, Janeri RD, Machado PS, Schvartsman

C, Santos OF. Managing patients with dengue fever during

an epidemic: the importance of a hydration tent and of a

multidisciplinary approach. BMC Res Notes. 2011;4(1):335.

Ahmad MH, Ibrahim MI, Mohamed Z, Ismail N, Abdullah MA,

Shueb RH, et al. The sensitivity, specificity and accuracy of warning

signs in predicting severe dengue, the severe dengue prevalence

and its associated factors. Int J Environ Res Public Health. 2018

Sep 15;15(9):2018.

Rosenberger KD, Lum L, Alexander N, Junghanss T, Wills B,

Jaenisch T; DENCO Clinical Study Group. Vascular leakage

in dengue--clinical spectrum and influence of parenteral fluid

therapy. Trop Med Int Health. 2016;21(3):445-53.

Kattan E, Castro R, Miralles-Aguiar F, Hernández G, Rola P. The

emerging concept of fluid tolerance: A position paper. J Crit Care.

;71:154070.

Prasetyo RV, Azis AL, Soegijanto S. Comparison of the efficacy

and safety of hydroxyethyl starch 130/0.4 and Ringer’s lactate

in children with grade III dengue hemorrhagic fever. Paediatr

Indones. 2009;49(2):97.

Dung NM, Day NP, Tam DT, Loan HT, Chau HT, Minh LN, et al. Fluid

replacement in dengue shock syndrome: a randomized, doubleblind

comparison of four intravenous-fluid regimens. Clin Infect

Dis. 1999;29(4):787-94.

Ngo NT, Cao XT, Kneen R, Wills B, Nguyen VM, Nguyen TQ, et

al. Acute management of dengue shock syndrome: a randomized

double-blind comparison of 4 intravenous fluid regimens in the

first hour. Clin Infect Dis. 2001;32(2):204-13.

Wills BA, Nguyen MD, Ha TL, Dong TH, Tran TN, Le TT, et al.

Comparison of three fluid solutions for resuscitation in dengue

shock syndrome. N Engl J Med. 2005;353(9):877-89.

Lewis SR, Pritchard MW, Evans DJ, Butler AR, Alderson P, Smith AF,

et al. Colloids versus crystalloids for fluid resuscitation in critically

ill people. Cochrane Database Syst Rev. 2018;8(8):CD000567.

Zampieri FG, Cavalcanti AB, Di Tanna GL, Damiani LP, Hammond

NE, Machado FR, et al. Balanced crystalloids versus saline

for critically ill patients (BEST-Living): a systematic review

and individual patient data meta-analysis. Lancet Respir Med.

;12(3):237-46.

Astapenko D, Navratil P, Pouska J, Cerny V. Clinical physiology

aspects of chloremia in fluid therapy: a systematic review. Perioper

Med. 2020;9(1):40.

Soff G, Leader A, Al-Samkari H, Falanga A, Maraveyas A,

Sanfilippo K, et al. Management of chemotherapy-induced

thrombocytopenia: guidance from the ISTH Subcommittee on

Hemostasis and Malignancy. J Thromb Haemost. 2024;22(1):53-

Sellahewa KH, Samaraweera N, Thusita KP, Fernando JL. Is fresh

frozen plasma effective for thrombocytopenia in adults with

dengue fever? A prospective randomised double blind controlled

study. Ceylon Med J. 2008;53(2):36-40.

Assir MZK, Kamran U, Ahmad HI, et al. Effectiveness of Platelet

Transfusion in Dengue Fever: A Randomized Controlled Trial.

Transfus Med Hemotherapy. 2013;40(5):362-8.

Lye DC, Archuleta S, Syed-Omar SF, Low JG, Oh HM, Wei Y, et

al. Prophylactic platelet transfusion plus supportive care versus

supportive care alone in adults with dengue and thrombocytopenia:

a multicentre, open-label, randomised, superiority trial. Lancet.

;389(10079):1611-8.

Lee TH, Wong JG, Leo YS, Thein TL, Ng EL, Lee LK, et al. Potential

Harm of Prophylactic Platelet Transfusion in Adult Dengue

Patients. PLoS Negl Trop Dis. 2016;10(3):e0004576.

Anthon CT, Granholm A, Sivapalan P, Zellweger N, Pène F, Puxty

K, et al. Prophylactic platelet transfusions versus no prophylaxis in

hospitalized patients with thrombocytopenia: A systematic review

with meta-analysis. Transfusion (Paris). 2022;62(10):2117-36.

van Baarle FL, van de Weerdt EK, van der Velden WJ, Ruiterkamp

RA, Tuinman PR, Ypma PF, et al. Platelet Transfusion before CVC

Placement in Patients with Thrombocytopenia. N Engl J Med.

;388(21):1956-65.

Melgarejo-Ortuño A, Ribed-Sánchez A, Giménez-Manzorro Á,

Zorrila-Ortúzar J, Sanjurjo-Saez M. Are we overdosing parenteral

metamizole? Cir Esp (Engl Ed). 2021;99(1):68-70.

Bhaskar E, Sowmya G, Moorthy S, Sundar V. Prevalence, patterns,

and factors associated with bleeding tendencies in dengue. J Infect

Dev Ctries. 2015;9(1):105-10.

Wang JY, Tseng CC, Lee CS, Cheng KP. Clinical and upper

gastroendoscopic features of patients with dengue virus infection.

J Gastroenterol Hepatol. 1990;5(6):664-8.

Wijewickrama A. Dengue, bleeding and non-steroidal antiinflammatory

drugs. J Ceylon Coll Physicians. 2017.

Díaz-Quijano FA, Villar-Centeno LA, Martínez-Vega RA. Efecto

de la administración temprana de dipirona sobre la gravedad

del dengue en una cohorte prospectiva. Enfermedades Infecc

Microbiol Clínica. 2005;23(10):593-7.

Diaz-Quijano FA, Villar-Centeno LA, Martinez-Vega RA. Predictors

of spontaneous bleeding in patients with acute febrile syndrome

from a dengue endemic area. J Clin Virol. 2010;49(1):11-5.

Busse JW, Sadeghirad B, Oparin Y, Chen E, Goshua A, May C, et al.

Management of Acute Pain From Non-Low Back, Musculoskeletal

Injuries : A Systematic Review and Network Meta-analysis of

Randomized Trials. Ann Intern Med. 2020;173(9):730-8.

Lesczinsky DM, Gutiérrez SP, Torrico A, Paz FT. Efectos de la

administración de dipirona en niños tratados por dengue con

signos de alarma. Rev Bol Ped. 2015;54(3).

Vasikasin V, Rojdumrongrattana T, Chuerboonchai W,

Siriwiwattana T, Thongtaeparak W, Niyasom S, et al. Effect of

standard dose paracetamol versus placebo as antipyretic therapy

on liver injury in adult dengue infection: a multicentre randomised

controlled trial. Lancet Glob Health. 2019;7(5):e664-70.

Pandejpong D, Saengsuri P, Rattarittamrong R, Rujipattanakul T,

Chouriyagune C. Is excessive acetaminophen intake associated

with transaminitis in adult patients with dengue fever? Intern Med

J. 2015;45(6):653-8.

Syed AA, Aslam F, Hakeem H, Siddiqui F, Nasir N. Frequency

of worsening liver function in severe dengue hepatitis patients

receiving paracetamol: A retrospective analysis of hospital data. J

Pak Med Assoc. 2017;67(3).

Thomas L, Brouste Y, Najioullah F, Hochedez P, Hatchuel Y,

Moravie V, et al. Predictors of severe manifestations in a cohort of

adult dengue patients. J Clin Virol. 2010;48(2):96-9.

Djossou F, Vesin G, Walter G, Epelboin L, Mosnier E, Bidaud B, et

al. Incidence and predictive factors of transaminase elevation in

patients consulting for dengue fever in Cayenne Hospital, French

Guiana. Trans R Soc Trop Med Hyg. 2016;110(2):134-40.

Gutierrez Lesmes OA, Plata Casas LI, Montaño Contreras SC.

Mortalidad en pacientes menores de edad con diagnóstico

de dengue y su relación con el uso de Dipirona. Univ Salud.

;18(3):550.

Rosaldo AR, Almaraz RT. Indicación del metamizol en pacientes

con dengue clásico y dengue hemorrágico. Med Interna México.

Kötter T, da Costa BR, Fässler M, Blozik E, Linde K, Jüni P, et al.

Metamizole-associated adverse events: a systematic review and

meta-analysis. PLoS One. 2015;10(4):e0122918.

Premaratna R, Ragupathy A, Miththinda JK, Silva HJ. Timing,

predictors, and progress of third space fluid accumulation during

preliminary phase fluid resuscitation in adult patients with dengue.

Int J Infect Dis IJID Off Publ Int Soc Infect Dis. 2013;17(7):e505-

Wongsa A. Fluid and hemodynamic management in severe dengue.

Southeast Asian J Trop Med Public Health. 2015;46 Suppl 1:123-

Michels M, Djamiatun K, Faradz SM, Koenders MM, de Mast Q,

van der Ven AJ. High plasma mid-regional pro-adrenomedullin

levels in children with severe dengue virus infections. J Clin Virol

Off Publ Pan Am Soc Clin Virol. 2011;50(1):8-12.

Andrews B, Semler MW, Muchemwa L, Kelly P, Lakhi S,

Heimburger DC, et al. Effect of an Early Resuscitation Protocol on

In-hospital Mortality Among Adults With Sepsis and Hypotension:

A Randomized Clinical Trial. JAMA. 2017;318(13):1233-40.

Russell JA, Walley KR, Singer J, Gordon AC, Hébert PC,

Cooper DJ, et al; VASST Investigators. Vasopressin versus

norepinephrine infusion in patients with septic shock. N Engl J

Med. 2008;358(9):877-87.

De Backer D, Biston P, Devriendt J, Madl C, Chochrad D,

Aldecoa C, et al.; SOAP II Investigators. Comparison of dopamine

and norepinephrine in the treatment of shock. N Engl J Med.

;362(9):779-89.

Jayaweera DK, Subasinghe S, De Silva RF, Sanjeewa WA,

Jayawickreme KP. Complicated dengue fever and its treatment

dilemmas: a single-center experience in Sri Lanka. Case Rep Infect

Dis. 2021;2021:8854282.

Rajapakse S. Dengue shock. J Emerg Trauma Shock. 2011;4(1):120-

Rossaint R, Afshari A, Bouillon B, Cerny V, Cimpoesu D, Curry N,

et al. The European guideline on management of major bleeding

and coagulopathy following trauma: sixth edition. Crit Care.

;27(1):80.

Publicado

2024-04-25

Como Citar

Oliveira J. e Silva, L., von Hellmann, R., Ward A. Maia, I., Brandão, R., Schubert, D., Marchini, J., Prync Flato, U. A., Lopes, P., Coester, A., Lunardi, M. C., Rocha, H., Ortigosa Nogueira, V., de Araújo Cunha, K., Benincá, V., Abrahão Hajjar, L. ., Garcia Alencar, J. C., & Penna Guimarães, H. (2024). Diretrizes clínicas da ABRAMEDE para o manejo de dengue em pacientes adultos na emergência. JBMEDE - Jornal Brasileiro De Medicina De Emergência, 4(2). https://doi.org/10.54143/jbmede.v4i2.199

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